The Administrative Core provides a cohesive administrative structure for scientists, the business administrator and consultants on the Program Project. Specifically, the Administrative Core: devotes 5% effort on behalf of the Core Leader to coordinate administrative activity of all Program Project personnel with the Business Administrator; arranges and schedules weekly meetings of Program Project investigators; monitors all grant expenditures; ensures compliance with NIH guidelines; provides monthly financial statements to investigators; orders all material necessary for scientific research; and provides support for 3 expert consultants each year, who visit Denver to critique all aspects of the Program Project.